Reactome | PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10153412
displayName	PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]
hasComponent	[Complex:R-RNO-1433549] GRB2:p-SHP2:p-KIT complex [plasma membrane] [EntityWithAccessionedSequence:R-RNO-912529] phospho-Gab2 [cytosol] [Complex:R-RNO-198379] PI3K alpha [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-1562561] PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] - Homo sapiens
maxDepth	7
memberOf	[DefinedSet:R-RNO-9031773] PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] - Rattus norvegicus
name	PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex
producedByEvent	[Reaction:R-RNO-1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2 - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1562561
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-RNO-1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2
(hasMember)	[DefinedSet:R-RNO-9031773] PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]
(inferredTo)	[Complex:R-HSA-1562561] PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]

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