Reactome | NFKB1(1-433):RELA [cytosol]

Schema > Complex > Entries

NFKB1(1-433):RELA [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-1168603] NF-kappaB p50:p65:IKB [cytosol] - Rattus norvegicus [Complex:R-RNO-193938] IkB(alpha):NF-kB complex [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-193691] NF-kB migrates to the nucleus and turns on transcription - Rattus norvegicus [Reaction:R-RNO-193700] p75NTR ICD signals to NF-kB - Rattus norvegicus [BlackBoxEvent:R-RNO-2730894] NFKB1:RELA translocates from the cytosol to the nucleus - Rattus norvegicus [BlackBoxEvent:R-RNO-9958872] RAC1, CDC42 activate NF?B - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122553
displayName	NFKB1(1-433):RELA [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-RNO-168168] Nfkb1 [cytosol] [EntityWithAccessionedSequence:R-RNO-168172] Rela [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-194043] NFKB1(1-433):RELA [cytosol] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-RNO-1168598] NF-kappaB p50,p65,c-Rel dimer [cytosol] - Rattus norvegicus
name	NFKB1(1-433):RELA
producedByEvent	[BlackBoxEvent:R-RNO-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Rattus norvegicus [BlackBoxEvent:R-RNO-209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex - Rattus norvegicus [Reaction:R-RNO-193705] IKKbeta phosphorylates IkB causing NF-kB to dissociate - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-194043
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-RNO-1168603] NF-kappaB p50:p65:IKB [cytosol] [Complex:R-RNO-1168611] NF-kappaB p50:p65:p-IKB [cytosol] [Complex:R-RNO-1168590] NF-kappaB p50:p65:ub-p-IKB [cytosol] [Complex:R-RNO-197481] NF-kB:p75NTR ICD:TRAF6 [cytosol] [Complex:R-RNO-193938] IkB(alpha):NF-kB complex [cytosol] [Complex:R-RNO-5607671] p-S32,36-IkB-alpha:NF-kB complex [cytosol] [Complex:R-RNO-5607697] K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol]
(hasMember)	[DefinedSet:R-RNO-1168598] NF-kappaB p50,p65,c-Rel dimer [cytosol]
(input)	[Reaction:R-RNO-193691] NF-kB migrates to the nucleus and turns on transcription [Reaction:R-RNO-193700] p75NTR ICD signals to NF-kB [BlackBoxEvent:R-RNO-2730894] NFKB1:RELA translocates from the cytosol to the nucleus [BlackBoxEvent:R-RNO-9958872] RAC1, CDC42 activate NF?B
(output)	[Reaction:R-RNO-193705] IKKbeta phosphorylates IkB causing NF-kB to dissociate [BlackBoxEvent:R-RNO-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex [BlackBoxEvent:R-RNO-209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
(inferredTo)	[Complex:R-HSA-194043] NFKB1(1-433):RELA [cytosol]

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