Reactome | Cyclin E:CDK2-mediated phosphorylation of RB1

Schema > Reaction > Entries

Cyclin E:CDK2-mediated phosphorylation of RB1 Show undefined attributes

catalystActivity	[CatalystActivity:10121005] cyclin-dependent protein serine/threonine kinase activity of CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10121007
displayName	Cyclin E:CDK2-mediated phosphorylation of RB1
eventOf	[Pathway:R-RNO-69200] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-113503] PP2A mediated localization of RB1 protein in chromatin - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-188390] Cyclin E:CDK2-mediated phosphorylation of RB1 - Homo sapiens
input	14 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-RNO-188373] CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cyclin E:CDK2-mediated phosphorylation of RB1
output	14 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-RNO-188362] Cyclin E:p-T160-CDK2 [nucleoplasm] 14 × [EntityWithAccessionedSequence:R-RNO-188389] phospho-Rb1 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-188386] Association of Rb with Cyclin E:Cdk2 complexes - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-188390
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-113503] PP2A mediated localization of RB1 protein in chromatin
(hasEvent)	[Pathway:R-RNO-69200] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
(inferredTo)	[Reaction:R-HSA-188390] Cyclin E:CDK2-mediated phosphorylation of RB1

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