Reactome | IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

Schema > Reaction > Entries

IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus Show undefined attributes

catalystActivity	[CatalystActivity:10158721] inositol hexakisphosphate kinase activity of IP6K1/2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10158723
displayName	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
eventOf	[Pathway:R-RNO-1855191] Synthesis of IPs in the nucleus - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1855224] 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus - Rattus norvegicus [Reaction:R-RNO-1855203] 5-PP-IP5 transports from the nucleus to the cytosol - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1855207] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-2023929] IP6 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
output	[SimpleEntity:R-ALL-2023940] 5-PP-IP5 [nucleoplasm] [SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
precedingEvent	[Reaction:R-RNO-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Rattus norvegicus [Reaction:R-RNO-1855188] IP6 transports from the cytosol to the nucleus - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1855207
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1855191] Synthesis of IPs in the nucleus
(precedingEvent)	[Reaction:R-RNO-1855224] 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus [Reaction:R-RNO-1855203] 5-PP-IP5 transports from the nucleus to the cytosol
(inferredTo)	[Reaction:R-HSA-1855207] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

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