Reactome | 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus

Schema > Reaction > Entries

1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus Show undefined attributes

catalystActivity	[CatalystActivity:10158531] diphosphoinositol pentakisphosphate kinase activity of IP6K1/2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10158533
displayName	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
eventOf	[Pathway:R-RNO-1855191] Synthesis of IPs in the nucleus - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1855220] (PP)2-IP4 transports from the nucleus to the cytosol - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1855157] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-2023932] 1-PP-IP5 [nucleoplasm] [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
output	[SimpleEntity:R-ALL-2023931] 1,5-(PP)2-IP4 [nucleoplasm] [SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
precedingEvent	[Reaction:R-RNO-1855212] 1/3-PP-IP5 transports from the cytosol to the nucleus - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1855157
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1855191] Synthesis of IPs in the nucleus
(precedingEvent)	[Reaction:R-RNO-1855220] (PP)2-IP4 transports from the nucleus to the cytosol
(inferredTo)	[Reaction:R-HSA-1855157] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus

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