Reactome | Shelterin complex [nucleoplasm]

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Shelterin complex [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-9629214] AP-Telomeric DNA:Shelterin [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-9668602] POLA:primase:G-strand extended telomere end [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-174434] RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-174435] Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10115685
displayName	Shelterin complex [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-RNO-174889] Acd [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-174890] Pot1 [nucleoplasm] [Complex:R-RNO-9671130] TERF1 homodimer [nucleoplasm] [Complex:R-RNO-9671119] TERF2 homodimer [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-RNO-174873] Terf2ip [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-174883] TINF2 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-174898] Shelterin complex [nucleoplasm] - Homo sapiens
maxDepth	3
name	Shelterin complex
producedByEvent	[BlackBoxEvent:R-RNO-3785711] Telomere shortening during replicative exhaustion - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-174898
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-RNO-9629214] AP-Telomeric DNA:Shelterin [nucleoplasm] [Complex:R-RNO-9629187] Gh-Telomeric DNA:Shelterin [nucleoplasm] [Complex:R-RNO-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] [Complex:R-RNO-9671076] Telomeric G-strand chromosome end:Shelterin [nucleoplasm] [Complex:R-RNO-164683] Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] [Complex:R-RNO-163098] Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] [Complex:R-RNO-164619] Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] [Complex:R-RNO-9671097] Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] [Complex:R-RNO-9668602] POLA:primase:G-strand extended telomere end [nucleoplasm] [Complex:R-RNO-174434] RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] [Complex:R-RNO-174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] [Complex:R-RNO-174450] RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] [Complex:R-RNO-174435] Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] [Complex:R-RNO-174431] Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] [Complex:R-RNO-174440] Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] [Complex:R-RNO-174432] Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] [Complex:R-RNO-176394] Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] [Complex:R-RNO-9690022] Extended And Processed Telomere End [nucleoplasm] [Complex:R-RNO-182751] Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm]
(output)	[BlackBoxEvent:R-RNO-3785711] Telomere shortening during replicative exhaustion
(inferredTo)	[Complex:R-HSA-174898] Shelterin complex [nucleoplasm]

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