Reactome | Shelterin complex [nucleoplasm]

Schema > Complex > Entries

Shelterin complex [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] - Homo sapiens [Complex:R-HSA-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] - Homo sapiens [Complex:R-HSA-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] - Homo sapiens [Complex:R-HSA-9629442] Tg-Telomeric DNA:Shelterin [nucleoplasm] - Homo sapiens [Complex:R-HSA-9668602] POLA:primase:G-strand extended telomere end [nucleoplasm] - Homo sapiens [Complex:R-HSA-174434] RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] - Homo sapiens [Complex:R-HSA-174435] Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-176700] Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure - Homo sapiens [Reaction:R-HSA-181450] Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure - Homo sapiens
created	[InstanceEdit:174877] Gillespie, ME, 2006-02-22 18:23:42
dbId	174898
displayName	Shelterin complex [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-174889] ACD [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-174890] POT1 [nucleoplasm] [Complex:R-HSA-9671130] TERF1 homodimer [nucleoplasm] [Complex:R-HSA-9671119] TERF2 homodimer [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-174873] TERF2IP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-174883] TINF2 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-174898] Shelterin complex [nucleoplasm] - Mus musculus [Complex:R-RNO-174898] Shelterin complex [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-174898] Shelterin complex [nucleoplasm] - Canis familiaris [Complex:R-BTA-174898] Shelterin complex [nucleoplasm] - Bos taurus [Complex:R-SSC-174898] Shelterin complex [nucleoplasm] - Sus scrofa [Complex:R-DRE-174898] Shelterin complex [nucleoplasm] - Danio rerio [Complex:R-XTR-174898] Shelterin complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-174898] Shelterin complex [nucleoplasm] - Gallus gallus
literatureReference	[LiteratureReference:9671128] In vivo stoichiometry of shelterin components [LiteratureReference:9671107] Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
maxDepth	3
modified	[InstanceEdit:9671138] Orlic-Milacic, Marija, 2019-12-18
name	Shelterin complex
producedByEvent	[BlackBoxEvent:R-HSA-3785711] Telomere shortening during replicative exhaustion - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-174898
updateTrackers	[UpdateTracker:9901088] Update Tracker - [Complex:174898] Shelterin complex [nucleoplasm] - v72:[addLiteratureReference, add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9901088] Update Tracker - [Complex:174898] Shelterin complex [nucleoplasm] - v72:[addLiteratureReference, add_removeHasComponent]
(hasComponent)	[Complex:R-HSA-9629442] Tg-Telomeric DNA:Shelterin [nucleoplasm] [Complex:R-HSA-9629401] Sp-Telomeric DNA:Shelterin [nucleoplasm] [Complex:R-HSA-9629214] AP-Telomeric DNA:Shelterin [nucleoplasm] [Complex:R-HSA-9629187] Gh-Telomeric DNA:Shelterin [nucleoplasm] [Complex:R-HSA-9670115] Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] [Complex:R-HSA-9671076] Telomeric G-strand chromosome end:Shelterin [nucleoplasm] [Complex:R-HSA-164683] Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] [Complex:R-HSA-163098] Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] [Complex:R-HSA-164684] Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] [Complex:R-HSA-164619] Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] [Complex:R-HSA-9671097] Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] [Complex:R-HSA-9668602] POLA:primase:G-strand extended telomere end [nucleoplasm] [Complex:R-HSA-174434] RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] [Complex:R-HSA-174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] [Complex:R-HSA-174450] RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] [Complex:R-HSA-174435] Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] [Complex:R-HSA-174431] Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] [Complex:R-HSA-174440] Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] [Complex:R-HSA-174432] Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] [Complex:R-HSA-176394] Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] [Complex:R-HSA-176703] Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] [Complex:R-HSA-9690022] Extended And Processed Telomere End [nucleoplasm] [Complex:R-HSA-182751] Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm]
(input)	[BlackBoxEvent:R-HSA-176700] Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure [Reaction:R-HSA-181450] Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure
(output)	[BlackBoxEvent:R-HSA-3785711] Telomere shortening during replicative exhaustion

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