Reactome | APC/C-mediated degradation of cell cycle proteins

Schema > Pathway > Entries

APC/C-mediated degradation of cell cycle proteins Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222641
displayName	APC/C-mediated degradation of cell cycle proteins
eventOf	[Pathway:R-RNO-453276] Regulation of mitotic cell cycle - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:161960] anaphase-promoting complex-dependent catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-RNO-176408] Regulation of APC/C activators between G1/S and early anaphase - Rattus norvegicus [Pathway:R-RNO-176814] Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins - Rattus norvegicus [Pathway:R-RNO-176407] Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase - Rattus norvegicus [Pathway:R-RNO-174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 - Rattus norvegicus [Pathway:R-RNO-174084] Autodegradation of Cdh1 by Cdh1:APC/C - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-174143] APC/C-mediated degradation of cell cycle proteins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	APC/C-mediated degradation of cell cycle proteins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-174143
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-453276] Regulation of mitotic cell cycle
(inferredTo)	[Pathway:R-HSA-174143] APC/C-mediated degradation of cell cycle proteins

© 2026 Reactome

Cite Us!