Reactome | beta-NGF dimer binds to TrkA receptor

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beta-NGF dimer binds to TrkA receptor Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10116991
displayName	beta-NGF dimer binds to TrkA receptor
eventOf	[Pathway:R-RNO-187042] TRKA activation by NGF - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-166538] The bound receptor dimerizes - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-166542] beta-NGF dimer binds to TrkA receptor - Homo sapiens
input	[Complex:R-RNO-193861] beta-NGF homodimer [extracellular region] [EntityWithAccessionedSequence:R-RNO-3008784] NTRK1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	beta-NGF dimer binds to TrkA receptor
output	[Complex:R-RNO-166537] beta-NGF dimer:TrkA receptor [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-166542
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-187042] TRKA activation by NGF
(precedingEvent)	[Reaction:R-RNO-166538] The bound receptor dimerizes
(inferredTo)	[Reaction:R-HSA-166542] beta-NGF dimer binds to TrkA receptor

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