Reactome | TRKA activation by NGF

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222801
displayName	TRKA activation by NGF
eventOf	[Pathway:R-RNO-187015] Activation of TRKA receptors - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:182] neurotrophin TRK receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-166542] beta-NGF dimer binds to TrkA receptor - Rattus norvegicus [Reaction:R-RNO-166538] The bound receptor dimerizes - Rattus norvegicus [BlackBoxEvent:R-RNO-190065] Activated TrkA receptor internalizes to endosomes - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-187042] TRKA activation by NGF - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TRKA activation by NGF
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-187042
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-187015] Activation of TRKA receptors
(inferredTo)	[Pathway:R-HSA-187042] TRKA activation by NGF