Reactome | beta-NGF dimer binds to TrkA receptor

Schema > Reaction > Entries

beta-NGF dimer binds to TrkA receptor Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:166541] Jassal, Bijay, 2005-09-08
dbId	166542
displayName	beta-NGF dimer binds to TrkA receptor
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-187042] TRKA activation by NGF - Homo sapiens
followingEvent	[Reaction:R-HSA-166538] The bound receptor dimerizes - Homo sapiens
input	[Complex:R-HSA-187031] mature beta-NGF homodimer [extracellular region] [EntityWithAccessionedSequence:R-HSA-3008784] NTRK1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:167058] The trk proto-oncogene encodes a receptor for nerve growth factor [LiteratureReference:167033] Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor [LiteratureReference:189682] The trk proto-oncogene product: a signal transducing receptor for nerve growth factor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	beta-NGF dimer binds to TrkA receptor
orthologousEvent	[Reaction:R-GGA-166542] beta-NGF dimer binds to TrkA receptor - Gallus gallus [Reaction:R-XTR-166542] beta-NGF dimer binds to TrkA receptor - Xenopus tropicalis [Reaction:R-DRE-166542] beta-NGF dimer binds to TrkA receptor - Danio rerio [Reaction:R-SSC-166542] beta-NGF dimer binds to TrkA receptor - Sus scrofa [Reaction:R-BTA-166542] beta-NGF dimer binds to TrkA receptor - Bos taurus [Reaction:R-CFA-166542] beta-NGF dimer binds to TrkA receptor - Canis familiaris [Reaction:R-RNO-166542] beta-NGF dimer binds to TrkA receptor - Rattus norvegicus [Reaction:R-MMU-166542] beta-NGF dimer binds to TrkA receptor - Mus musculus
output	[Complex:R-HSA-166537] beta-NGF dimer:TrkA receptor [plasma membrane]
precedingEvent	[Reaction:R-HSA-167014] pro-beta-NGF homodimer transits to the golgi apparatus - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166542
summation	[Summation:167042] Neurotrophin dimer binding to TRK receptors causes receptor ...
updateTrackers	[UpdateTracker:9787624] Update Tracker - [Reaction:166542] beta-NGF dimer binds to TrkA receptor - v44:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9787624] Update Tracker - [Reaction:166542] beta-NGF dimer binds to TrkA receptor - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-187042] TRKA activation by NGF
(precedingEvent)	[Reaction:R-HSA-166538] The bound receptor dimerizes