Reactome | mTORC1-mediated signalling

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mTORC1-mediated signalling Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222783
displayName	mTORC1-mediated signalling
eventOf	[Pathway:R-RNO-165159] MTOR signalling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-165718] mTORC1 phosphorylation of RPS6KB1 (S6K) - Rattus norvegicus [Reaction:R-RNO-165726] Phosphorylation of Ribosomal protein S6 by activated S6K1 - Rattus norvegicus [Reaction:R-RNO-165758] Phosphorylation and inactivation of eEF2K by activated S6K1 - Rattus norvegicus [Reaction:R-RNO-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Rattus norvegicus [Reaction:R-RNO-9679044] FKBP1A binds sirolimus - Rattus norvegicus [Reaction:R-RNO-165692] Phosphorylation of 4E-BP1 by activated mTORC1 - Rattus norvegicus [Reaction:R-RNO-165708] Dissociation of phosphorylated 4EBP1 from eIF4E - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-166208] mTORC1-mediated signalling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	mTORC1-mediated signalling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-166208
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-165159] MTOR signalling
(inferredTo)	[Pathway:R-HSA-166208] mTORC1-mediated signalling

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