Reactome | Phosphorylation of 4E-BP1 by activated mTORC1

Schema > Reaction > Entries

Phosphorylation of 4E-BP1 by activated mTORC1 Show undefined attributes

catalystActivity	[CatalystActivity:10116692] protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10116706
displayName	Phosphorylation of 4E-BP1 by activated mTORC1
eventOf	[Pathway:R-RNO-166208] mTORC1-mediated signalling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-165708] Dissociation of phosphorylated 4EBP1 from eIF4E - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-165692] Phosphorylation of 4E-BP1 by activated mTORC1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-72581] eIF4E:4E-BP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of 4E-BP1 by activated mTORC1
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-165697] eIF4E:4E-BP1-P [cytosol]
precedingEvent	[Reaction:R-RNO-165680] Formation of active mTORC1 complex - Rattus norvegicus [Reaction:R-RNO-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Rattus norvegicus
regulatedBy	[NegativeRegulation:10116707] Negative regulation by 'mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]' [NegativeRegulation:10116708] Negative regulation by 'FKBP1A:sirolimus [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-165692
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-166208] mTORC1-mediated signalling
(precedingEvent)	[Reaction:R-RNO-165708] Dissociation of phosphorylated 4EBP1 from eIF4E
(inferredTo)	[Reaction:R-HSA-165692] Phosphorylation of 4E-BP1 by activated mTORC1

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