Reactome | mTORC1 phosphorylation of RPS6KB1 (S6K)

Schema > Reaction > Entries

mTORC1 phosphorylation of RPS6KB1 (S6K) Show undefined attributes

catalystActivity	[CatalystActivity:10116692] protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10116741
displayName	mTORC1 phosphorylation of RPS6KB1 (S6K)
eventOf	[Pathway:R-RNO-166208] mTORC1-mediated signalling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-165758] Phosphorylation and inactivation of eEF2K by activated S6K1 - Rattus norvegicus [Reaction:R-RNO-165726] Phosphorylation of Ribosomal protein S6 by activated S6K1 - Rattus norvegicus [Reaction:R-RNO-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-165718] mTORC1 phosphorylation of RPS6KB1 (S6K) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-RNO-9975788] RPS6KB1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	mTORC1 phosphorylation of RPS6KB1 (S6K)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-RNO-9975784] p-T389/412-RPS6KB1 [cytosol]
precedingEvent	[Reaction:R-RNO-165680] Formation of active mTORC1 complex - Rattus norvegicus [Reaction:R-RNO-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Rattus norvegicus
regulatedBy	[NegativeRegulation:10116742] Negative regulation by 'mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]' [NegativeRegulation:10116708] Negative regulation by 'FKBP1A:sirolimus [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-165718
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-166208] mTORC1-mediated signalling
(precedingEvent)	[Reaction:R-RNO-165758] Phosphorylation and inactivation of eEF2K by activated S6K1 [Reaction:R-RNO-165726] Phosphorylation of Ribosomal protein S6 by activated S6K1 [Reaction:R-RNO-165766] Phosphorylation and activation of eIF4G by activated S6K1
(inferredTo)	[Reaction:R-HSA-165718] mTORC1 phosphorylation of RPS6KB1 (S6K)