Reactome | factor XIIa [extracellular region]

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factor XIIa [extracellular region] Show undefined attributes

catalystActivities	[CatalystActivity:10114786] serine-type endopeptidase activity of factor XIIa [extracellular region]
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-RNO-9653860] HRG:factor XIIa [extracellular region] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9653879] factor XIIa binds HRG - Rattus norvegicus [Reaction:R-RNO-9655840] FXIIa is cleaved to ?-FXIIa - Rattus norvegicus [Reaction:R-RNO-158357] factor XIIa binds SERPING1 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10114785
displayName	factor XIIa [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-RNO-158285] F12 [extracellular region] [EntityWithAccessionedSequence:R-RNO-158320] F12 [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-158306] factor XIIa [extracellular region] - Homo sapiens
maxDepth	2
name	factor XIIa
producedByEvent	[Reaction:R-RNO-158313] factor XII -> factor XIIa - Rattus norvegicus [Reaction:R-RNO-9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) - Rattus norvegicus [Reaction:R-RNO-9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) - Rattus norvegicus [Reaction:R-RNO-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-158306
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-RNO-9653860] HRG:factor XIIa [extracellular region] [Complex:R-RNO-158141] factor XIIa:C1Inh [extracellular region]
(input)	[Reaction:R-RNO-9653879] factor XIIa binds HRG [Reaction:R-RNO-9655840] FXIIa is cleaved to ?-FXIIa [Reaction:R-RNO-158357] factor XIIa binds SERPING1
(output)	[Reaction:R-RNO-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) [Reaction:R-RNO-158313] factor XII -> factor XIIa [Reaction:R-RNO-9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) [Reaction:R-RNO-9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)
(physicalEntity)	[CatalystActivity:10114786] serine-type endopeptidase activity of factor XIIa [extracellular region]
(inferredTo)	[Complex:R-HSA-158306] factor XIIa [extracellular region]

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