Reactome | factor XIIa binds SERPING1

Schema > Reaction > Entries

factor XIIa binds SERPING1 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10114875
displayName	factor XIIa binds SERPING1
eventOf	[Pathway:R-RNO-9855719] Regulation of FXIIa and plasma kallikrein activity - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
inferredFrom	[Reaction:R-HSA-158357] factor XIIa binds SERPING1 - Homo sapiens
input	[Complex:R-RNO-158306] factor XIIa [extracellular region] [EntityWithAccessionedSequence:R-RNO-158296] Serping1 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XIIa binds SERPING1 factor XIIa + C1Inh -> factor XIIa:C1Inh
output	[Complex:R-RNO-158141] factor XIIa:C1Inh [extracellular region]
precedingEvent	[Reaction:R-RNO-158313] factor XII -> factor XIIa - Rattus norvegicus [BlackBoxEvent:R-RNO-9650473] SERPING1 is secreted - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-158357
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9855719] Regulation of FXIIa and plasma kallikrein activity
(inferredTo)	[Reaction:R-HSA-158357] factor XIIa binds SERPING1

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