Reactome | Binding of IP3 to IP3 receptor

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Binding of IP3 to IP3 receptor Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:114521] platelet dense tubular network membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10113429
displayName	Binding of IP3 to IP3 receptor
eventOf	[Pathway:R-RNO-114508] Effects of PIP2 hydrolysis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-139941] Binding of IP3 to IP3 receptor - Homo sapiens
input	[SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol] [Complex:R-RNO-418292] IP3R tetramer [platelet dense tubular network membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of IP3 to IP3 receptor
output	[Complex:R-RNO-139839] IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane]
precedingEvent	[Reaction:R-RNO-114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - Rattus norvegicus [Reaction:R-RNO-114689] PLC gamma 2-mediated PIP2 hydrolysis - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-139941
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-114508] Effects of PIP2 hydrolysis
(precedingEvent)	[Reaction:R-RNO-139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol
(inferredTo)	[Reaction:R-HSA-139941] Binding of IP3 to IP3 receptor