Reactome | PLC-beta hydrolyses PIP2 to DAG and IP3

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PLC-beta hydrolyses PIP2 to DAG and IP3 Show undefined attributes

catalystActivity	[CatalystActivity:10113190] C-type glycerophospholipase activity of PLC beta:G alpha (q/11) [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10113192
displayName	PLC-beta hydrolyses PIP2 to DAG and IP3
eventOf	[Pathway:R-RNO-416476] G alpha (q) signalling events - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-114553] Activation of conventional Protein Kinase C - Rattus norvegicus [Reaction:R-RNO-426209] DAG activation of TRPC channels - Rattus norvegicus [Reaction:R-RNO-426240] DAG kinase produces phosphatidic acid from DAG - Rattus norvegicus [Reaction:R-RNO-426032] DAG is metabolized by DAGL to 2-AG - Rattus norvegicus [Reaction:R-RNO-425861] Activation of Protein Kinase C novel isoforms - Rattus norvegicus [Reaction:R-RNO-139941] Binding of IP3 to IP3 receptor - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - Homo sapiens
input	[Complex:R-RNO-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PLC-beta hydrolyses PIP2 to DAG and IP3
output	[Complex:R-RNO-8983509] PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-114688
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-114553] Activation of conventional Protein Kinase C [Reaction:R-RNO-426209] DAG activation of TRPC channels [Reaction:R-RNO-426240] DAG kinase produces phosphatidic acid from DAG [Reaction:R-RNO-426032] DAG is metabolized by DAGL to 2-AG [Reaction:R-RNO-425861] Activation of Protein Kinase C novel isoforms [Reaction:R-RNO-139941] Binding of IP3 to IP3 receptor
(hasEvent)	[Pathway:R-RNO-416476] G alpha (q) signalling events
(inferredTo)	[Reaction:R-HSA-114688] PLC-beta hydrolyses PIP2 to DAG and IP3