Reactome | IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol

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IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10113265] calcium channel activity of IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane]
category	transition
compartment	[Compartment:114521] platelet dense tubular network membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10113267
displayName	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol
eventOf	[Pathway:R-RNO-139853] Elevation of cytosolic Ca2+ levels - Rattus norvegicus [Pathway:R-RNO-114508] Effects of PIP2 hydrolysis - Rattus norvegicus [Pathway:R-RNO-5578775] Ion homeostasis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-114553] Activation of conventional Protein Kinase C - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-139827] Ca2+ [platelet dense tubular network lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol Transport of Ca++ from platelet dense tubular system to cytoplasm
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
precedingEvent	[Reaction:R-RNO-139941] Binding of IP3 to IP3 receptor - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-139854
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5578775] Ion homeostasis [Pathway:R-RNO-139853] Elevation of cytosolic Ca2+ levels [Pathway:R-RNO-114508] Effects of PIP2 hydrolysis
(precedingEvent)	[Reaction:R-RNO-114553] Activation of conventional Protein Kinase C
(inferredTo)	[Reaction:R-HSA-139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol

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