Reactome | PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine

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PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151076
displayName	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine
eventOf	[Pathway:R-RNO-1169091] Activation of NF-kappaB in B cells - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine - Homo sapiens
input	3 × [SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [SimpleEntity:R-ALL-114519] DAG [plasma membrane] [EntityWithAccessionedSequence:R-RNO-58198] PRKCB [cytosol] [SimpleEntity:R-ALL-33625] PS [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine Protein Kinase C beta (PKC-beta, PRKCB) is activated
output	[Complex:R-RNO-139829] Activated PKC beta [plasma membrane]
precedingEvent	[Reaction:R-RNO-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1168373
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1169091] Activation of NF-kappaB in B cells
(precedingEvent)	[BlackBoxEvent:R-RNO-1168635] PRKCB (PKC-beta) phosphorylates CARMA1
(inferredTo)	[Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine

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