Reactome | MyD88:MAL(TIRAP) cascade initiated on plasma membrane

Schema > Pathway > Entries

created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11128716
displayName	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
eventOf	[Pathway:R-PFA-166016] Toll Like Receptor 4 (TLR4) Cascade - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259820] MyD88-dependent toll-like receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-PFA-450294] MAP kinase activation - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-166058
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-PFA-166016] Toll Like Receptor 4 (TLR4) Cascade [Pathway:R-PFA-168179] Toll Like Receptor TLR1:TLR2 Cascade [Pathway:R-PFA-168188] Toll Like Receptor TLR6:TLR2 Cascade
(hasEncapsulatedEvent)	[Pathway:R-PFA-5686938] Regulation of TLR by endogenous ligand
(inferredTo)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane

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