Reactome | E-cadherin strand dimer degradation by Casp3

Schema > Reaction > Entries

authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:2534230] serine-type endopeptidase activity of Caspase-3 tetramer [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2534268] Jupe, S, 2012-10-24
dbId	2534247
displayName	E-cadherin strand dimer degradation by Casp3
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
input	[GenomeEncodedEntity:R-CFA-2534284] Cadherin-1 [plasma membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202809] Cleavage and shedding of E-cadherin after induction of apoptosis [LiteratureReference:3827970] The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E-cadherin strand dimer degradation by Casp3
orthologousEvent	[Reaction:R-HSA-2534260] E-cadherin degradation by caspase-3 and calpain-1 - Homo sapiens
output	[GenomeEncodedEntity:R-CFA-2534168] Cadherin-1 C-term fragment [plasma membrane] [GenomeEncodedEntity:R-CFA-2534172] Cadherin-1 N-term fragment [plasma membrane]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:49646] Canis familiaris
stId	R-NUL-2534247
summation	[Summation:3827982] Caspase-3 (Steinhusen et al. 2001) and calpain-1 (Rios-Doria...

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