E-cadherin strand dimer degradation by Casp3

Stable Identifier
R-NUL-2534247
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E-cadherin strand dimer degradation by Casp3
Caspase-3 (Steinhusen et al. 2001) and calpain-1 (Rios-Doria et al. 2003) cleave E-cadherin in its cytoplasmic part releasing an intracellular 37 kDa C-terminal fragment termed CTF3.
Literature References
PubMed ID Title Journal Year
11076937 Cleavage and shedding of E-cadherin after induction of apoptosis

Steinhusen, U, Weiske, J, Badock, V, Tauber, R, Bommert, K, Huber, O

J. Biol. Chem. 2001
12393869 The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells

Rios-Doria, J, Day, KC, Kuefer, R, Rashid, MG, Chinnaiyan, AM, Rubin, MA, Day, ML

J. Biol. Chem. 2003
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of Caspase-3 tetramer [cytosol]

Physical Entity
Caspase-3 tetramer [cytosol] (Mus musculus)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-24)
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