Reactome | FBXW7 mediates ubiquitination of phosphorylated NICD1

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FBXW7 mediates ubiquitination of phosphorylated NICD1 Show undefined attributes

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:2064880] ubiquitin-protein transferase activity of p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2064882] Orlic-Milacic, M, 2012-01-19
dbId	2064883
displayName	FBXW7 mediates ubiquitination of phosphorylated NICD1
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
input	[Complex:R-NUL-2064852] p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2064850] The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog [LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FBXW7 mediates ubiquitination of phosphorylated NICD1
orthologousEvent	[Reaction:R-HSA-1852623] Ubiquitination of NICD1 by FBWX7 - Homo sapiens
output	[Complex:R-HSA-1604469] FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [Complex:R-NUL-2064879] Ub,p-NICD1 [nucleoplasm]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus
stId	R-NUL-2064883
summation	[Summation:2064888] A recombinant mouse NICD1 was shown to be ubiquitinated upon...

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