FBXW7 mediates ubiquitination of phosphorylated NICD1

Stable Identifier
R-NUL-2064883
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FBXW7 mediates ubiquitination of phosphorylated NICD1
A recombinant mouse NICD1 was shown to be ubiquitinated upon binding to recombinant human FBXW7 (Oberg et al. 2001), which is followed by NICD1 degradation (Fyer et al. 2004). Ubiquitination and degradation of NICD1 by FBXW7 is dependent on PEST sequence in Notch.
Literature References
PubMed ID Title Journal Year
11461910 The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

Oberg, C, Li, J, Pauley, A, Wolf, E, Gurney, M, Lendahl, U

J Biol Chem 2001
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
Participants
Input
Output
Catalyst Activity

ubiquitin-protein transferase activity of p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]

Physical Entity
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Ubiquitination of NICD1 by FBWX7 (Homo sapiens)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-19)
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