Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut

Stable Identifier
R-NUL-1250472
Type
Reaction
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut

Sos1 bound to exogenously expressed human GRB2 in complex with phosphorylated mouse Shc1 and phosphorylated rat oncoprotein Erbb2mut catalyzes guanyl-nucleotide exchange on endogenous Ras in mouse fibroblasts (Xie et al. 1995).

Literature References
Participants
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of GRB2:Sos1:P-Shc1:P-Erbb2mut [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created