Reactome | Stat6, Nfatc2, and Nicd1,2 positiively regulate expression of Gata3

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Stat6, Nfatc2, and Nicd1,2 positiively regulate expression of Gata3 Show undefined attributes

authored	[InstanceEdit:9978005] May, Bruce, 2025-12-24
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9978007] May, Bruce, 2025-12-27
dbId	9977991
displayName	Stat6, Nfatc2, and Nicd1,2 positiively regulate expression of Gata3
edited	[InstanceEdit:9978005] May, Bruce, 2025-12-24
input	[EntityWithAccessionedSequence:R-MMU-9830509] Gata3 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9976105] STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells [LiteratureReference:9942710] Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation [LiteratureReference:9976107] Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor [LiteratureReference:9977600] Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch [LiteratureReference:9977594] Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells [LiteratureReference:9977768] Notch directly regulates Gata3 expression during T helper 2 cell differentiation
maxDepth	1
modified	[InstanceEdit:9983731] May, Bruce, 2026-02-26
name	Stat6, Nfatc2, and Nicd1,2 positiively regulate expression of Gata3
orthologousEvent	[BlackBoxEvent:R-HSA-9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-9830515] Gata3 [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9977995] Positive gene expression regulation by 'Mll1:Men1:p-Y641-Stat6:p-S245-Nfatc2:Notch1,2 Coactivator:Gata3 gene [nucleoplasm]'
regulationReference	[RegulationReference:9977971] Positive gene expression regulation by 'Mll1:Men1:p-Y641-Stat6:p-S245-Nfatc2:Notch1,2 Coactivator:Gata3 gene [nucleoplasm]' STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9977991
summation	[Summation:9978006] Phosphorylated Stat6 dimers resulting from Il4 signaling and...

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