Phosphorylated Stat6 dimers resulting from Il4 signaling and...

created [InstanceEdit:9978007] May, Bruce, 2025-12-27
dbId 9978006
displayName Phosphorylated Stat6 dimers resulting from Il4 signaling and...
modified [InstanceEdit:9979259] May, Bruce, 2026-01-16
schemaClass Summation
text Phosphorylated Stat6 dimers resulting from Il4 signaling and dephosphorylated Nfatc2 (Nfat) resulting from T cell receptor signaling bind the Gata3 gene and activate expression (Scheinman and Avni 2009, Wei et al. 2010, Onodera et al. 2010). Phosphorylated Stat6 dimers recruit Mll1 complexes to positively regulate transcription (Onodera et al. 2010). Activation of Notch1,2 signaling by Jagged located on antigen presenting cells results in generation of Nicd1,2, the intracellular cleavage product of Notch1,2, which binds Rbpj at the upstream promoter of the Gata3 gene and recruits coactivators to enhance transcription (Amsen et al. 2004, 2007, Fang et al. 2007).
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