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Schema
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Reaction
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Entries
Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene
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authored
[InstanceEdit:9978005] May, Bruce, 2025-12-24
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9978007] May, Bruce, 2025-12-27
dbId
9977982
displayName
Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene
edited
[InstanceEdit:9978005] May, Bruce, 2025-12-24
input
[EntityWithAccessionedSequence:R-MMU-9966546] Batf [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9977947] Ets1 [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9830515] Gata3 [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9966550] Irf4 [nucleoplasm]
[Complex:R-MMU-9977972] p-Y641-Stat6 dimer [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9977999] Pou2f1 [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9977949] Pou2f2 [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9978001] Rad50 gene [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9977987] Satb1 [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-9727480] Smarca4 [nucleoplasm]
[EntityWithAccessionedSequence:R-MMU-5619454] Yy1 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9977777] Regulation of the Th2 cytokine locus by a locus control region
[LiteratureReference:9977781] Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region
[LiteratureReference:9977943] BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity
[LiteratureReference:9977988] Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation
[LiteratureReference:9977990] Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3
[LiteratureReference:9978003] RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4
[LiteratureReference:9977957] SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes
[LiteratureReference:9977938] BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells
maxDepth
1
modified
[InstanceEdit:9983731] May, Bruce, 2026-02-26
name
Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene
orthologousEvent
[Reaction:R-HSA-9977764] GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene - Homo sapiens
output
[Complex:R-MMU-9977961] Gata3:Yy1:Ets1:Pou2f1:Pou2f2:Batf:Irf4:Satb1:Smarca4:p-Y641-Stat6:Rad50 gene [nucleoplasm]
previousReviewStatus
[ReviewStatus:9821383] three stars
releaseDate
2026-03-25
releaseStatus
NEW
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24
[InstanceEdit:9983730] Lord, Graham M, 2026-02-26
schemaClass
Reaction
species
[Species:48892] Mus musculus
stId
R-MMU-9977982
summation
[Summation:9978015] The Rad50 gene is located in the 120 kb gene cluster on mous...
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