Reactome | GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene

Schema > Reaction > Entries

GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene Show undefined attributes

authored	[InstanceEdit:9977616] May, Bruce, 2025-12-22
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9977778] May, Bruce, 2025-12-23
dbId	9977764
displayName	GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene
edited	[InstanceEdit:9977616] May, Bruce, 2025-12-22
eventOf	[Pathway:R-HSA-9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9976402] GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13 - Homo sapiens [BlackBoxEvent:R-HSA-9976140] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, MAF, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL4 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9977982] Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-6789925] BATF [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1629809] ETS1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-996768] GATA3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9907101] IRF4 [nucleoplasm] [Complex:R-HSA-6786281] p-Y641-STAT6 dimer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-83836] POU2F1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6814932] POU2F2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9977776] RAD50 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-201593] SATB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-201686] SMARCA4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4086091] YY1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
maxDepth	1
modified	[InstanceEdit:9983731] May, Bruce, 2026-02-26
name	GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene
output	[Complex:R-HSA-9977761] GATA3:YY1:ETS1:POU2F1:POU2F2:BATF:p-Y641-STAT6:SATB1:IRF4:SMARCA4:RAD50 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9977764
summation	[Summation:9977770] The genes encoding the Th2 cytokines IL4, IL13, and IL5 are ...

Referrals

(hasEvent)	[Pathway:R-HSA-9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)
(precedingEvent)	[BlackBoxEvent:R-HSA-9976402] GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13 [BlackBoxEvent:R-HSA-9976140] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, MAF, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL4
(inferredTo)	[Reaction:R-MMU-9977982] Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene

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