Reactome | proHPSE dissociates from HS(6)-SDC1

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proHPSE dissociates from HS(6)-SDC1 Show undefined attributes

category	dissociation
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10097670
displayName	proHPSE dissociates from HS(6)-SDC1
eventOf	[Pathway:R-MMU-2024096] HS-GAG degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-9792568] CTSL1 cleaves proHPSE - Mus musculus [Reaction:R-MMU-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Mus musculus
inferredFrom	[Reaction:R-HSA-9941078] proHPSE dissociates from HS(6)-SDC1 - Homo sapiens
input	[Complex:R-MMU-9792577] proHPSE:SDC1 [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	proHPSE dissociates from HS(6)-SDC1
output	[EntityWithAccessionedSequence:R-MMU-9792563] proHPSE [lysosomal lumen] [EntityWithAccessionedSequence:R-MMU-2090082] Sdc1 [lysosomal lumen]
precedingEvent	[BlackBoxEvent:R-MMU-9792581] proHPSE:SDC1 is delivered to lysosomes - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9941078
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-MMU-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) [BlackBoxEvent:R-MMU-9792568] CTSL1 cleaves proHPSE
(inferredTo)	[Reaction:R-HSA-9941078] proHPSE dissociates from HS(6)-SDC1

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