Reactome | proHPSE dissociates from HS(6)-SDC1

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proHPSE dissociates from HS(6)-SDC1 Show undefined attributes

authored	[InstanceEdit:9941010] Stephan, Ralf, 2025-02-10
category	dissociation
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
dbId	9941078
displayName	proHPSE dissociates from HS(6)-SDC1
edited	[InstanceEdit:9948077] Stephan, Ralf, 2025-05-15
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9792568] CTSL1 cleaves proHPSE - Homo sapiens [Reaction:R-HSA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Homo sapiens
input	[Complex:R-HSA-9792577] proHPSE:SDC1 [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9792572] Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and ?-actinin
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	proHPSE dissociates from HS(6)-SDC1
orthologousEvent	[Reaction:R-BTA-9941078] proHPSE dissociates from HS(6)-SDC1 - Bos taurus [Reaction:R-DME-9941078] proHPSE dissociates from HS(6)-SDC1 - Drosophila melanogaster [Reaction:R-GGA-9941078] proHPSE dissociates from HS(6)-SDC1 - Gallus gallus [Reaction:R-XTR-9941078] proHPSE dissociates from HS(6)-SDC1 - Xenopus tropicalis [Reaction:R-SSC-9941078] proHPSE dissociates from HS(6)-SDC1 - Sus scrofa [Reaction:R-CFA-9941078] proHPSE dissociates from HS(6)-SDC1 - Canis familiaris [Reaction:R-RNO-9941078] proHPSE dissociates from HS(6)-SDC1 - Rattus norvegicus [Reaction:R-MMU-9941078] proHPSE dissociates from HS(6)-SDC1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-2090082] HS(6)-SDC1 [lysosomal lumen] [EntityWithAccessionedSequence:R-HSA-9792563] proHPSE [lysosomal lumen]
precedingEvent	[BlackBoxEvent:R-HSA-9792581] proHPSE:SDC1 is delivered to lysosomes - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9948076] D'Eustachio, Peter, 2025-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9941078
summation	[Summation:9941205] The molecular mechanism underlying internalization of the pr...

Referrals

(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[BlackBoxEvent:R-HSA-9792568] CTSL1 cleaves proHPSE [Reaction:R-HSA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)