Reactome | CTSL1 cleaves proHPSE

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CTSL1 cleaves proHPSE Show undefined attributes

catalystActivity	[CatalystActivity:10093123] cysteine-type endopeptidase activity of CTSL1(114-288) [lysosomal lumen]
category	omitted
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10093125
displayName	CTSL1 cleaves proHPSE
eventOf	[Pathway:R-MMU-2024096] HS-GAG degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:172710] zymogen activation
inferredFrom	[BlackBoxEvent:R-HSA-9792568] CTSL1 cleaves proHPSE - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-9792563] proHPSE [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CTSL1 cleaves proHPSE
output	[Complex:R-MMU-1666976] HPSE dimer [lysosomal lumen]
precedingEvent	[Reaction:R-MMU-9941078] proHPSE dissociates from HS(6)-SDC1 - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9792568
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-MMU-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
(inferredTo)	[BlackBoxEvent:R-HSA-9792568] CTSL1 cleaves proHPSE

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