Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2

Stable Identifier
R-MMU-9932501
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2
The Fbxl3:Cul1:Skp1:Rbx1 SCF E3 ligase complex polyubiqutinylates unknown lysine residues in Cry1 (Yoo et al. 2013, Hirano et al. 2013) and Cry2 (Busino et al. 2007). Multiple lysines on Cry1 appear to be capable of being ubiquitinylated (Yoo et al. 2013). The linkage between ubiquitin residues in the polyubiquitin chains occurs at lysine-48 (K48) of ubiquitin (Hirano et al. 2013).
Literature References
PubMed ID Title Journal Year
23452856 FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes

Hirano, A, Yumimoto, K, Tsunematsu, R, Matsumoto, M, Oyama, M, Kozuka-Hata, H, Nakagawa, T, Lanjakornsiripan, D, Nakayama, KI, Fukada, Y

Cell 2013
17463251 SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

Busino, L, Bassermann, F, Maiolica, A, Lee, C, Nolan, PM, Godinho, SI, Draetta, GF, Pagano, M

Science 2007
23452855 Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm

Yoo, SH, Mohawk, JA, Siepka, SM, Shan, Y, Huh, SK, Hong, HK, Kornblum, I, Kumar, V, Koike, N, Xu, M, Nussbaum, J, Liu, X, Chen, Z, Chen, ZJ, Green, CB, Takahashi, JS

Cell 2013
Participants
Input
Output
Orthologous Events
FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 (Homo sapiens)
Authored
May, B  (2024-12-20)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-20)
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