Reactome | Rora,c and coactivators positively regulate expression of Clock

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Rora,c and coactivators positively regulate expression of Clock Show undefined attributes

authored	[InstanceEdit:9932068] May, Bruce, 2024-12-15
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9932069] May, Bruce, 2024-12-17
dbId	9932080
displayName	Rora,c and coactivators positively regulate expression of Clock
edited	[InstanceEdit:9932068] May, Bruce, 2024-12-15
input	[EntityWithAccessionedSequence:R-MMU-5667083] Clock gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5669309] System-level identification of transcriptional circuits underlying mammalian circadian clocks [LiteratureReference:9926652] Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice [LiteratureReference:9911573] ROR? directly regulates the circadian expression of clock genes and downstream targets in vivo [LiteratureReference:1368179] Direct regulation of CLOCK expression by REV-ERB
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Rora,c and coactivators positively regulate expression of Clock
orthologousEvent	[BlackBoxEvent:R-HSA-9932070] RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-508720] Clock [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:R-MMU-5667070] Negative gene expression regulation by 'Nr1d1:heme:Corepressors:Clock gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9932077] Positive gene expression regulation by 'Rora,c:Coactivators:Clock gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9931507] Positive gene expression regulation by 'Sirt1 [nucleoplasm]'
regulationReference	[RegulationReference:9932076] Positive gene expression regulation by 'Rora,c:Coactivators:Clock gene [nucleoplasm]' ROR? directly regulates the circadian expression of clock genes and downstream targets in vivo [RegulationReference:9932071] Negative regulation by 'Nr1d1:heme:Corepressors:Clock gene [nucleoplasm]' Direct regulation of CLOCK expression by REV-ERB [RegulationReference:9931526] Positive gene expression regulation by 'Sirt1 [nucleoplasm]' SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9932080
summation	[Summation:9932075] The Clock gene is transcribed in a circadian pattern to yiel...