Reactome | RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK

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RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK Show undefined attributes

authored	[InstanceEdit:9932069] May, Bruce, 2024-12-17
category	uncertain
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9932069] May, Bruce, 2024-12-17
dbId	9932070
displayName	RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK
edited	[InstanceEdit:9932069] May, Bruce, 2024-12-17
eventOf	[Pathway:R-HSA-9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 - Homo sapiens
followingEvent	[Reaction:R-HSA-9912396] CDK5 phosphorylates CLOCK on serine-451 and serine-461 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9932080] Rora,c and coactivators positively regulate expression of Clock - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5640211] CLOCK gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1368902] Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK
output	[EntityWithAccessionedSequence:R-HSA-400392] CLOCK [cytosol]
precedingEvent	[Reaction:R-HSA-9932081] RORA,C and coactivators bind the CLOCK gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-1368175] Negative gene expression regulation by 'NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5656490] Positive gene expression regulation by 'SIRT1 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5656508] Positive gene expression regulation by 'RAI1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9932083] Positive gene expression regulation by 'RORA,C:Coactivators:CLOCK gene [nucleoplasm]'
regulationReference	[RegulationReference:9642512] Positive gene expression regulation by 'RAI1 [nucleoplasm]' Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9932070
summation	[Summation:9932085] The CLOCK gene is transcribed (Steeves et al. 1999) in a cir... [Summation:5656485] Inferred from mouse homologs, RAI1 increases transcription o...

Referrals

(hasEvent)	[Pathway:R-HSA-9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2
(precedingEvent)	[Reaction:R-HSA-9912396] CDK5 phosphorylates CLOCK on serine-451 and serine-461
(inferredTo)	[BlackBoxEvent:R-MMU-9932080] Rora,c and coactivators positively regulate expression of Clock

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