Reactome | SPOP-mediated degradation of CD274 by 26S Proteosome

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SPOP-mediated degradation of CD274 by 26S Proteosome Show undefined attributes

catalystActivity	[CatalystActivity:9985423] endopeptidase activity of 26S proteasome [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10096593
displayName	SPOP-mediated degradation of CD274 by 26S Proteosome
eventOf	[Pathway:R-MMU-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Homo sapiens
input	[Complex:R-MMU-9929485] polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SPOP-mediated degradation of CD274 by 26S Proteosome
output	[Complex:R-MMU-9929377] SPOP:CUL3:RBX1 [cytosol] 3 × [DefinedSet:R-MMU-113595] Ub [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9929486
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274)
(inferredTo)	[Reaction:R-HSA-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome

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