Reactome | TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]

catalystActivities	[CatalystActivity:10093413] K63-linked deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] [CatalystActivity:10093462] Met1-linked polyubiquitin deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-MMU-9818787] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] - Mus musculus
consumedByEvent	[BlackBoxEvent:R-MMU-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Mus musculus [Reaction:R-MMU-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex - Mus musculus [BlackBoxEvent:R-MMU-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10054129
displayName	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
hasComponent	[CandidateSet:R-MMU-5357900] BIRC2,3,4 [cytosol] [Complex:R-MMU-9796690] CYLD:SPATA2:LUBAC [cytosol] [EntityWithAccessionedSequence:R-MMU-9793681] K63,M1polyUb-RIPK1 [cytosol] [DefinedSet:R-MMU-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-MMU-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-MMU-66370] Traf2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] - Homo sapiens
maxDepth	5
memberOf	[DefinedSet:R-MMU-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] - Mus musculus
name	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD
negativelyRegulates	[NegativeRegulation:10093407] Negative regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]'
producedByEvent	[BlackBoxEvent:R-MMU-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-9817363
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-MMU-9818787] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane]
(input)	[BlackBoxEvent:R-MMU-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex [Reaction:R-MMU-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex [BlackBoxEvent:R-MMU-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex
(physicalEntity)	[CatalystActivity:10093413] K63-linked deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] [CatalystActivity:10093462] Met1-linked polyubiquitin deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
(regulator)	[NegativeRegulation:10093407] Negative regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]'
(output)	[BlackBoxEvent:R-MMU-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex
(hasMember)	[DefinedSet:R-MMU-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane]
(inferredTo)	[Complex:R-HSA-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]

TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] Show undefined attributes

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