Reactome | Negative regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]'

Schema > NegativeRegulation > Entries

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10093407
displayName	Negative regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]'
regulatedEntity	[BlackBoxEvent:R-MMU-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Mus musculus
regulator	[Complex:R-MMU-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]
schemaClass	NegativeRegulation

(regulatedBy)

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