Reactome | XDH dehydrogenates hypoxanthine to form xanthine

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XDH dehydrogenates hypoxanthine to form xanthine Show undefined attributes

authored	[InstanceEdit:9727345] D'Eustachio, Peter, 2021-04-15
catalystActivity	[CatalystActivity:9727348] hypoxanthine dehydrogenase activity of XDH dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9727344] hypoxanthine dehydrogenase activity of XDH dimer [cytosol] Cloning and expression in vitro of human xanthine dehydrogenase/oxidase
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9727345] D'Eustachio, Peter, 2021-04-15
crossReference	[DatabaseIdentifier:11881149] Rhea:24671
dbId	9727347
displayName	XDH dehydrogenates hypoxanthine to form xanthine
edited	[InstanceEdit:9727345] D'Eustachio, Peter, 2021-04-15
eventOf	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9727349] XDH dehydrogenates xanthine to form urate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-113599] Hyp [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9727338] Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans [LiteratureReference:200234] Cloning and expression in vitro of human xanthine dehydrogenase/oxidase [LiteratureReference:500147] Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	XDH dehydrogenates hypoxanthine to form xanthine Hypoxanthine + H2O + NAD+ => Xanthine + NADH + H+
orthologousEvent	[Reaction:R-DDI-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Dictyostelium discoideum [Reaction:R-CEL-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Caenorhabditis elegans [Reaction:R-DME-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Drosophila melanogaster [Reaction:R-GGA-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Gallus gallus [Reaction:R-XTR-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Xenopus tropicalis [Reaction:R-SSC-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Sus scrofa [Reaction:R-BTA-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Bos taurus [Reaction:R-CFA-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Canis familiaris [Reaction:R-RNO-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Rattus norvegicus [Reaction:R-MMU-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-30064] XAN [cytosol]
precedingEvent	[Reaction:R-HSA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Homo sapiens [FailedReaction:R-HSA-9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9731185] Jassal, Bijay, 2021-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9727347
summation	[Summation:9727346] Cytosolic xanthine dehydrogenase (XDH) in its dehydrogenase ...

Referrals

(hasEvent)	[Pathway:R-HSA-74259] Purine catabolism
(precedingEvent)	[Reaction:R-HSA-9727349] XDH dehydrogenates xanthine to form urate