Eif2ak4 phosphorylates Eif2s1

Stable Identifier
R-MMU-9633504
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Eif2ak4 phosphorylates Eif2s1
After binding uncharged tRNA and autophosphorylating, Eif2ak4 (Gcn2) phosphorylates Eif2s1 (Eif2 alpha subunit) on serine-52 (Berlanga et al. 1999, Sood et al. 2000, and inferred from yeast homologs).
Literature References
PubMed ID Title Journal Year
10504407 Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

Berlanga, JJ, De Haro, C, Santoyo, J

Eur. J. Biochem. 1999
10655230 A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

Porter, AC, Wek, RC, Cavener, DR, Olsen, DA, Sood, R

Genetics 2000
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of tRNA:p-T898-Eif2ak4:Gcn1:80S ribosome:mRNA [cytosol]

Physical Entity
tRNA:p-T898-Eif2ak4:Gcn1:80S ribosome:mRNA [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
GCN2 phosphorylates SUI2 (Saccharomyces cerevisiae)
Orthologous Events
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
Authored
May, B  (2018-12-29)
Reviewed
Staschke, KA  (2019-11-20)
Bruhat, A  (2019-09-15)
Created
May, B  (2018-12-29)
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