Reactome | Active FLT3:GRB2 binds GAB2

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Active FLT3:GRB2 binds GAB2 Show undefined attributes

authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9606626] Varusai, Thawfeek, 2018-04-24
dbId	9606624
diseaseReaction	[Reaction:R-HSA-9698000] FLT3 mutants:GRB2 bind GAB2 - Homo sapiens
displayName	Active FLT3:GRB2 binds GAB2
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9606622] GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated - Homo sapiens
inferredFrom	[Reaction:R-MMU-9606623] Active Flt3:Grb2 binds Gab2 - Mus musculus
input	[Complex:R-HSA-9604756] Active FLT3: GRB2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-508239] GAB2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active FLT3:GRB2 binds GAB2
output	[Complex:R-HSA-9606619] Active FLT3:GRB2:GAB2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9604738] Active FLT3 dimer binds GRB2 - Homo sapiens
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9606624
summation	[Summation:9606620] Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...

Referrals

(hasEvent)	[Pathway:R-HSA-9607240] FLT3 Signaling
(normalReaction)	[Reaction:R-HSA-9698000] FLT3 mutants:GRB2 bind GAB2
(precedingEvent)	[BlackBoxEvent:R-HSA-9606622] GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
(inferredTo)	[Reaction:R-MMU-9606623] Active Flt3:Grb2 binds Gab2

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