Reactome | Active Flt3 binds Ptpn11

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Active Flt3 binds Ptpn11 Show undefined attributes

authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9604971] Varusai, Thawfeek, 2018-04-06
dbId	9604980
displayName	Active Flt3 binds Ptpn11
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
followingEvent	[Reaction:R-MMU-9645128] Activators bind Stat5 - Mus musculus
input	[Complex:R-MMU-9604748] Active Flt3 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-210002] Ptpn11 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9604777] Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 [LiteratureReference:9604970] The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active Flt3 binds Ptpn11
orthologousEvent	[Reaction:R-HSA-9604969] Active FLT3 binds PTPN11 - Homo sapiens
output	[Complex:R-MMU-9604978] Active Flt3:Ptpn11 [plasma membrane]
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9604980
summation	[Summation:9604968] Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a me...

Referrals

(precedingEvent)

[Reaction:R-MMU-9645128] Activators bind Stat5

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