Active Flt3 binds Ptpn11

Stable Identifier
R-MMU-9604980
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Active Flt3 binds Ptpn11

Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) has been reported to directly bind to the Y599 site of Flt3 receptors thereby facilitating downstream regulation of effectors (Heiss et al. 2006, Nabinger et al. 2013). Interaction of Flt3 with Ptpn11 is known to trigger Stat5 activation in various pathological conditions.

Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, SC, Li, XJ, Ramdas, B, He, Y, Zhang, X, Zeng, L, Richine, B, Bowling, JD, Fukuda, S, Goenka, S, Liu, Z, Feng, GS, Yu, M, Sandusky, GE, Boswell, HS, Zhang, ZY, Kapur, R, Chan, RJ

Leukemia 2013
16684964 Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

Heiss, E, Masson, K, Sundberg, C, Pedersen, M, Sun, J, Bengtsson, S, Rönnstrand, L

Blood 2006
Participants
Orthologous Events
Authored
Reviewed
Created