Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a me...

created [InstanceEdit:9604971] Varusai, Thawfeek, 2018-04-06
dbId 9604968
displayName Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a me...
modified [InstanceEdit:9645140] Varusai, Thawfeek, 2019-05-04
schemaClass Summation
text Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) has been reported to directly bind to the Y599 site of Flt3 receptors thereby facilitating downstream regulation of effectors (Heiss et al. 2006, Nabinger et al. 2013). Interaction of Flt3 with Ptpn11 is known to trigger Stat5 activation in various pathological conditions.
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