Reactome | Negative regulation of NOTCH4 signaling

Schema > Pathway > Entries

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101765
displayName	Negative regulation of NOTCH4 signaling
eventOf	[Pathway:R-MMU-9013694] Signaling by NOTCH4 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-9604328] AKT1 phosphorylates NOTCH4 - Mus musculus
inferredFrom	[Pathway:R-HSA-9604323] Negative regulation of NOTCH4 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Negative regulation of NOTCH4 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9604323
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-9013694] Signaling by NOTCH4
(inferredTo)	[Pathway:R-HSA-9604323] Negative regulation of NOTCH4 signaling

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