Reactome | Signaling by NOTCH4

Schema > Pathway > Entries

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101763
displayName	Signaling by NOTCH4
eventOf	[Pathway:R-MMU-157118] Signaling by NOTCH - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-MMU-9013700] NOTCH4 Activation and Transmission of Signal to the Nucleus - Mus musculus [Pathway:R-MMU-9604323] Negative regulation of NOTCH4 signaling - Mus musculus
inferredFrom	[Pathway:R-HSA-9013694] Signaling by NOTCH4 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by NOTCH4
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9013694
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-157118] Signaling by NOTCH
(hasEncapsulatedEvent)	[Pathway:R-MMU-1912422] Pre-NOTCH Expression and Processing
(inferredTo)	[Pathway:R-HSA-9013694] Signaling by NOTCH4

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