Reactome | Negative regulation of NOTCH4 signaling

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Negative regulation of NOTCH4 signaling Show undefined attributes

authored	[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
created	[InstanceEdit:9604324] Orlic-Milacic, Marija, 2018-04-02
dbId	9604323
displayName	Negative regulation of NOTCH4 signaling
edited	[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9013694] Signaling by NOTCH4 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9604328] AKT1 phosphorylates NOTCH4 - Homo sapiens [Reaction:R-HSA-9604387] p-4S-NICD4 binds YWHAZ - Homo sapiens [BlackBoxEvent:R-HSA-9604606] Unknown kinase phosphorylates NICD4 - Homo sapiens [Reaction:R-HSA-9604629] FBXW7 promotes ubiquitination of p-NICD4 - Homo sapiens [BlackBoxEvent:R-HSA-9604642] Proteasome degrades ubiquitinated NICD4 - Homo sapiens [Reaction:R-HSA-9604675] NICD4 binds to TACC3 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9604316] AKT and 14-3-3 regulate Notch4 nuclear localization [LiteratureReference:9604734] Elongin C is a mediator of Notch4 activity in human renal tubule cells [LiteratureReference:9017864] Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats [LiteratureReference:9604588] Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development [LiteratureReference:2064869] SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation [LiteratureReference:9605457] Trp53 regulates Notch 4 signaling through Mdm2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Negative regulation of NOTCH4 signaling
orthologousEvent	[Pathway:R-CEL-9604323] Negative regulation of NOTCH4 signaling - Caenorhabditis elegans [Pathway:R-DME-9604323] Negative regulation of NOTCH4 signaling - Drosophila melanogaster [Pathway:R-GGA-9604323] Negative regulation of NOTCH4 signaling - Gallus gallus [Pathway:R-RNO-9604323] Negative regulation of NOTCH4 signaling - Rattus norvegicus [Pathway:R-MMU-9604323] Negative regulation of NOTCH4 signaling - Mus musculus
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608066] Haw, Robin, 2018-05-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9604323
summation	[Summation:9604325] NOTCH4 signaling can be negatively regulated at the level of...

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(hasEvent)

[Pathway:R-HSA-9013694] Signaling by NOTCH4