Reactome | CBL binds CRK

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10021660
displayName	CBL binds CRK
eventOf	[Pathway:R-MMU-912631] Regulation of signaling by CBL - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-912734] CBL:CRKL binds RAPGEF1 - Mus musculus
inferredFrom	[Reaction:R-HSA-912790] CBL binds CRK - Homo sapiens
input	[DefinedSet:R-MMU-381945] CRK, CRKL [cytosol] [EntityWithAccessionedSequence:R-MMU-912656] phospho-p-Y700,Y731,Y774-CBL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL binds CRK
output	[Complex:R-MMU-912774] p(Y700,731,774)-CBL:CRK [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-912790
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-912631] Regulation of signaling by CBL
(precedingEvent)	[Reaction:R-MMU-912734] CBL:CRKL binds RAPGEF1
(inferredTo)	[Reaction:R-HSA-912790] CBL binds CRK