Reactome | CBL binds CRK

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CBL binds CRK Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:912797] Jupe, S, 2010-07-13
dbId	912790
displayName	CBL binds CRK
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-912631] Regulation of signaling by CBL - Homo sapiens
followingEvent	[Reaction:R-HSA-912734] CBL:CRKL binds RAPGEF1 - Homo sapiens
input	[DefinedSet:R-HSA-381945] CRK, CRKL [cytosol] [EntityWithAccessionedSequence:R-HSA-912656] p-Y700,Y731,Y774-CBL [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:912775] The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain [LiteratureReference:912771] Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CBL binds CRK
orthologousEvent	[Reaction:R-DME-912790] CBL binds CRK - Drosophila melanogaster [Reaction:R-CEL-912790] CBL binds CRK - Caenorhabditis elegans [Reaction:R-GGA-912790] CBL binds CRK - Gallus gallus [Reaction:R-DRE-912790] CBL binds CRK - Danio rerio [Reaction:R-SSC-912790] CBL binds CRK - Sus scrofa [Reaction:R-BTA-912790] CBL binds CRK - Bos taurus [Reaction:R-CFA-912790] CBL binds CRK - Canis familiaris [Reaction:R-RNO-912790] CBL binds CRK - Rattus norvegicus [Reaction:R-MMU-912790] CBL binds CRK - Mus musculus
output	[Complex:R-HSA-912774] p(Y700,731,774)-CBL:CRK [cytosol]
precedingEvent	[Reaction:R-HSA-912629] CBL is tyrosine phosphorylated - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-912790
summation	[Summation:912786] The Crk adapter protein family is comprised of Crk-I and Crk...
updateTrackers	[UpdateTracker:9782800] Update Tracker - [Reaction:912790] CBL binds CRK - v58:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9782800] Update Tracker - [Reaction:912790] CBL binds CRK - v58:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-912631] Regulation of signaling by CBL
(precedingEvent)	[Reaction:R-HSA-912734] CBL:CRKL binds RAPGEF1